Enoki, Winter Mushroom · 2018 · Research Support, Non U.S. Gov'T
High relevanceStructural elucidation of a polysaccharide from Flammulina velutipes and its immunomodulation activities on mouse B lymphocytes.
Flammulina velutipes
Key points
- A novel polysaccharide FVPB2 was purified from fruiting bodies of Flammulina velutipes
- Its structure was elucidated by monosaccharide composition and methylation analyses, UV-Visible and FTIR spectroscopy as well as NMR. FVPB2 was a homogeneous heteropolysaccharide (molecular weight ~ 1.50 × 10 4 Da) containing D-galactose, D-mannose, L-fucose, and D-glucose at molar ratio of 1.9:1.2:1:2.5
- In vitro immunomodulatory studies showed FVPB2 induced proliferation of mouse spleen lymphocytes in a dose-dependent manner
- The levels of IgM and IgG, secreted by B cells, increased after FVPB2 treatment
- So FVPB2 has potential to be a new important immunomodulatory nutraceutical
Metadata-grounded summary
Citation abstract
A novel polysaccharide FVPB2 was purified from fruiting bodies of Flammulina velutipes. Its structure was elucidated by monosaccharide composition and methylation analyses, UV-Visible and FTIR spectroscopy as well as NMR. FVPB2 was a homogeneous heteropolysaccharide (molecular weight ~ 1.50 × 10 4 Da) containing D-galactose, D-mannose, L-fucose, and D-glucose at molar ratio of 1.9:1.2:1:2.5. In vitro immunomodulatory studies showed FVPB2 induced proliferation of mouse spleen lymphocytes in a dose-dependent manner. The levels of IgM and IgG, secreted by B cells, increased after FVPB2 treatment. So FVPB2 has potential to be a new important immunomodulatory nutraceutical.
Citation
Wang WH, Zhang JS, Feng T, Deng J, Lin CC, Fan H, et al. (2018). Structural elucidation of a polysaccharide from Flammulina velutipes and its immunomodulation activities on mouse B lymphocytes. Scientific reports https://doi.org/10.1038/s41598-018-21375-0 PMID: 29449636
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