The polysaccharide-peptide complex from mushroom Cordyceps militaris ameliorates atherosclerosis by modulating the lncRNA-miRNA-mRNA axis.

Ophiocordyceps sinensis

Immune supportEnergy & fatigueRespiratory

SpeciesCordyceps, Caterpillar Fungus

JournalFood & function

Year2022

Key points

An N -glycosidic polysaccharide-peptide complex CMPS-80 was obtained from the fruiting body of C. militaris
Of importance, CMPS-80 significantly ameliorated formation of atherosclerotic lesions and plasma lipid profiles in apolipoprotein E-deficient mice
Integrated informatics analysis suggested that CMPS-80 can modulate multiple lncRNA-microRNA-mRNA axes
CMPS-80 has a potential application for prevention of hyperlipidemia and atherosclerosis

Metadata-grounded summary

Citation abstract

An N -glycosidic polysaccharide-peptide complex CMPS-80 was obtained from the fruiting body of C. militaris. Of importance, CMPS-80 significantly ameliorated formation of atherosclerotic lesions and plasma lipid profiles in apolipoprotein E-deficient mice. Integrated informatics analysis suggested that CMPS-80 can modulate multiple lncRNA-microRNA-mRNA axes. CMPS-80 has a potential application for prevention of hyperlipidemia and atherosclerosis.

Citation

Li Y, Miao M, Yin F, Shen N, Yu WQ, Guo SD (2022). The polysaccharide-peptide complex from mushroom Cordyceps militaris ameliorates atherosclerosis by modulating the lncRNA-miRNA-mRNA axis. Food & function https://doi.org/10.1039/d1fo03285b PMID: 35225320

Open citation