Niu-Chang-Chih · 2023 · Research Support, Non U.S. Gov'T
High relevanceRegio-specific enzymatic glucosylation of triterpenoids from Antrodia camphorata and their biological activities.
Antrodia camphorata
Key points
- The bacterial glycosyltransferase YjiC1 was used to glycosylate triterpenoids from the medicinal fungus Antrodia camphorata
- Eleven new compounds were obtained from enzymatic reactions
- Glucosylation could increase the inhibitory activities against COX-2, and improve the anti-inflammatory activities of Antrodia ergostanes on acute lung injury mice, especially (25 R )-antcin C 7- O-β -D-glucoside
Metadata-grounded summary
Citation abstract
The bacterial glycosyltransferase YjiC1 was used to glycosylate triterpenoids from the medicinal fungus Antrodia camphorata. Eleven new compounds were obtained from enzymatic reactions. Glucosylation could increase the inhibitory activities against COX-2, and improve the anti-inflammatory activities of Antrodia ergostanes on acute lung injury mice, especially (25 R )-antcin C 7- O-β -D-glucoside.
Citation
Su HF, Li B, Yi Y, Zhang M, Yu R, Bao YO, et al. (2023). Regio-specific enzymatic glucosylation of triterpenoids from Antrodia camphorata and their biological activities. Organic & biomolecular chemistry https://doi.org/10.1039/d3ob01286g PMID: 37842833
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