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Turkey Tail, Yun Zhi · 2023 · Research Support, Non U.S. Gov'T

Medium relevance

Direct arene trifluoromethylation enabled by promiscuous activity of fungal laccase.

Trametes versicolor

OncologyImmune support
SpeciesTurkey Tail, Yun Zhi
JournalOrganic & biomolecular chemistry
Year2023

Key points

  • Laccase from Trametes versicolor was found to oxidize non-phenolic arenes and enable the trifluoromethylation of arenes in the presence of in situ generated CF 3 radicals at a catalyst loading as low as 0.0034%
  • The biocatalytic trifluoromethylation proceeded under mild conditions and could increase the yield by up to 12 fold, compared to the control

Metadata-grounded summary

Citation abstract

Laccase from Trametes versicolor was found to oxidize non-phenolic arenes and enable the trifluoromethylation of arenes in the presence of in situ generated CF 3 radicals at a catalyst loading as low as 0.0034%. The biocatalytic trifluoromethylation proceeded under mild conditions and could increase the yield by up to 12 fold, compared to the control.

Citation

Goh YL, Long SYP, Wong MFE, Tan LL, Tiong E, Wong FT, et al. (2023). Direct arene trifluoromethylation enabled by promiscuous activity of fungal laccase. Organic & biomolecular chemistry https://doi.org/10.1039/d3ob01779f PMID: 37933470

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