Turkey Tail, Yun Zhi · 2023 · Research Support, Non U.S. Gov'T
Medium relevanceDirect arene trifluoromethylation enabled by promiscuous activity of fungal laccase.
Trametes versicolor
Key points
- Laccase from Trametes versicolor was found to oxidize non-phenolic arenes and enable the trifluoromethylation of arenes in the presence of in situ generated CF3 radicals at a catalyst loading as low as 0.0034%
- The biocatalytic trifluoromethylation proceeded under mild conditions and could increase the yield by up to 12 fold, compared to the control
From the paper
Abstract
Laccase from Trametes versicolor was found to oxidize non-phenolic arenes and enable the trifluoromethylation of arenes in the presence of in situ generated CF3 radicals at a catalyst loading as low as 0.0034%. The biocatalytic trifluoromethylation proceeded under mild conditions and could increase the yield by up to 12 fold, compared to the control.
Citation
Goh YL, Long SYP, Wong MFE, Tan LL, Tiong E, Wong FT, et al. (2023). Direct arene trifluoromethylation enabled by promiscuous activity of fungal laccase. Organic & biomolecular chemistry https://doi.org/10.1039/d3ob01779f PMID: 37933470
Open citation