Zhu Ling, Umbrella Polypore · 2010 · Research Support, Non U.S. Gov'T
Medium relevanceCytotoxic steroids from Polyporus umbellatus.
Polyporus umbellatus
Key points
- The steroids ergone (1), (22E, 24R)-ergosta-7,22-dien-3β-ol (2), 5α,8α-epidioxy-(22E,24R) -ergosta-6,22-dien-3β-ol (3), ergosta-6,22-dien-3β,5α,6β-triol (4), and polyporusterone B (5) were isolated from Polyporus umbellatus by bioassay-guided approach
- They showed potent anticancer activity against HepG2 cells
- Ergone displayed remarkable anticancer activity against HepG2, Hep-2, and Hela cancer cells, of which HepG2 cells were the most sensitive
- Furthermore, the cytotoxic effects of ergone on normal human cells (HUVEC) were smaller than on cancer cells
- The results showed that ergone had more selective cytotoxic activity against cancer cells than against normal cells
Metadata-grounded summary
Citation abstract
The steroids ergone (1), (22E, 24R)-ergosta-7,22-dien-3β-ol (2), 5α,8α-epidioxy-(22E,24R) -ergosta-6,22-dien-3β-ol (3), ergosta-6,22-dien-3β,5α,6β-triol (4), and polyporusterone B (5) were isolated from Polyporus umbellatus by bioassay-guided approach. They showed potent anticancer activity against HepG2 cells. Ergone displayed remarkable anticancer activity against HepG2, Hep-2, and Hela cancer cells, of which HepG2 cells were the most sensitive. Furthermore, the cytotoxic effects of ergone on normal human cells (HUVEC) were smaller than on cancer cells. The results showed that ergone had more selective cytotoxic activity against cancer cells than against normal cells.
Citation
Zhao YY, Chao X, Zhang Y, Lin RC, Sun WJ (2010). Cytotoxic steroids from Polyporus umbellatus. Planta medica https://doi.org/10.1055/s-0030-1249926 PMID: 20458671
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