Snow Fungus, Silver Ear · 1998 · Research Support, Non U.S. Gov'T
Low relevanceConjugates of Tremella polysaccharides with microbeads and their TNF-stimulating activity.
Tremella fuciformis
Key points
- A mannan (A) and a heteroglycan (D) were prepared by partial acidic hydrolysis of T3, a major polysaccharide fraction of the fungus Tremella fuciformis Berk
- Methylation analysis of A and D showed that they contained a 1-->3 linked mannosyl main chain, to which were linked different side chains at position 2, 4, or 6 of the mannosyl residues
- A and D were conjugated to albumin microbeads (AM) by reductive amination
- The conjugates showed significant cytokine-stimulating activity in vitro whereas unconjugated AM had no activity
- Not conjugated A and D showed cytokine-stimulating activity only in about 100 times higher concentrations
Metadata-grounded summary
Citation abstract
A mannan (A) and a heteroglycan (D) were prepared by partial acidic hydrolysis of T3, a major polysaccharide fraction of the fungus Tremella fuciformis Berk. Methylation analysis of A and D showed that they contained a 1-->3 linked mannosyl main chain, to which were linked different side chains at position 2, 4, or 6 of the mannosyl residues. A and D were conjugated to albumin microbeads (AM) by reductive amination. The conjugates showed significant cytokine-stimulating activity in vitro whereas unconjugated AM had no activity. Not conjugated A and D showed cytokine-stimulating activity only in about 100 times higher concentrations.
Citation
Gao Q, Berntzen G, Jiang R, Killie MK, Seljelid R (1998). Conjugates of Tremella polysaccharides with microbeads and their TNF-stimulating activity. Planta medica https://doi.org/10.1055/s-2006-957512 PMID: 9741303
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