Back to search

Snow Fungus, Silver Ear · 1996 · Research Support, Non U.S. Gov'T

Medium relevance

Characterization and cytokine stimulating activities of heteroglycans from Tremella fuciformis.

Tremella fuciformis

Immune supportGut & microbiomeSkin & hydration
SpeciesSnow Fungus, Silver Ear
JournalPlanta medica
Year1996

Key points

  • Three heteroglycans, T1a, T1b, and T1c, have been isolated from the body of Tremella fuciformis Berk
  • According to methylation analysis and partial acidic hydrolysis the main chains of T1a, T1b, and T1c consisted of (1-->3)-linked Man, which was branched at the 2, 4, or 6 positions
  • The branching points were linked with nonreducing terminal GIcA-residues or (1-->6)-linked glucan-chains
  • Molecular weights of the three heteroglycans are 53,000, 18,000, and 12,000 D respectively, but they undergo self-aggregation in water
  • T1a-T1c induce human monocytes to produce interleukin-1 (IL-1), interleukin-6 (IL-6), and tumor necrosis factor (TNF) in vitro
  • Acidic hydrolysate fractions of T1a (T1a-1, 2, 3, 4, 5) with molecular weight from 53,000 to 1,000 D, also induce human monocytes to produce IL-6 as efficient as T1a

Metadata-grounded summary

Citation abstract

Three heteroglycans, T1a, T1b, and T1c, have been isolated from the body of Tremella fuciformis Berk. They are composed of mannose (Man), xylose (Xyl), glucose (Glc), fucose (Fuc), and glucuronic acid (GlcA). According to methylation analysis and partial acidic hydrolysis the main chains of T1a, T1b, and T1c consisted of (1-->3)-linked Man, which was branched at the 2, 4, or 6 positions. The branching points were linked with nonreducing terminal GIcA-residues or (1-->6)-linked glucan-chains. Molecular weights of the three heteroglycans are 53,000, 18,000, and 12,000 D respectively, but they undergo self-aggregation in water. T1a-T1c induce human monocytes to produce interleukin-1 (IL-1), interleukin-6 (IL-6), and tumor necrosis factor (TNF) in vitro. Acidic hydrolysate fractions of T1a (T1a-1, 2, 3, 4, 5) with molecular weight from 53,000 to 1,000 D, also induce human monocytes to produce IL-6 as efficient as T1a.

Citation

Gao QP, Jiang RZ, Chen HQ, Jensen E, Seljelid R (1996). Characterization and cytokine stimulating activities of heteroglycans from Tremella fuciformis. Planta medica https://doi.org/10.1055/s-2006-957888 PMID: 8792658

Open citation