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Niu-Chang-Chih · 2007 · Research Support, Non U.S. Gov'T

Medium relevance

A new cytotoxic agent from solid-state fermented mycelium of Antrodia camphorata.

Antrodia camphorata

OncologyCognition & nervesLiver support
SpeciesNiu-Chang-Chih
JournalPlanta medica
Year2007

Key points

  • Antroquinonol ( 1), an ubiquinone derivative, was isolated from the solid-state fermented mycelium of Antrodia camphorata (Polyporaceae, Aphyllophorales), a parasitic fungus indigenous to Taiwan
  • The structure of compound 1 was elucidated by the analysis of their spectroscopic data
  • Its cytotoxic activities were evaluated against MCF-7, MDA-MB-231 (human breast carcinoma), Hep3B, HepG2 (human liver carcinoma) and DU-145, LNCaP (human prostate carcinoma) cell lines, and the IC (50) values ranged from 0.13 +/- 0.02 to 6.09 +/- 0.07 microM

Metadata-grounded summary

Citation abstract

Antroquinonol ( 1), an ubiquinone derivative, was isolated from the solid-state fermented mycelium of Antrodia camphorata (Polyporaceae, Aphyllophorales), a parasitic fungus indigenous to Taiwan. The structure of compound 1 was elucidated by the analysis of their spectroscopic data. Its cytotoxic activities were evaluated against MCF-7, MDA-MB-231 (human breast carcinoma), Hep3B, HepG2 (human liver carcinoma) and DU-145, LNCaP (human prostate carcinoma) cell lines, and the IC (50) values ranged from 0.13 +/- 0.02 to 6.09 +/- 0.07 microM.

Citation

Lee TH, Lee CK, Tsou WL, Liu SY, Kuo MT, Wen WC (2007). A new cytotoxic agent from solid-state fermented mycelium of Antrodia camphorata. Planta medica https://doi.org/10.1055/s-2007-990232 PMID: 17932820

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