Enoki, Winter Mushroom · 2023 · Journal Article
High relevanceTwo new sesquiterpenoids from plant endophytic fungus Flammulina velutipes.
Flammulina velutipes
Key points
- Two new sesquiterpenoids, flammupin A ( 1 ) and flammupin B ( 2 ), along with two known compounds, enokipodin C ( 3 ) and 5,5'-dibuthoxy-2,2'-bifuran ( 4 ) were obtained from Flammulina velutipes, an endophytic fungus isolated from the roots of Caulophyllum robustum Maxim
- The structures were elucidated by the combination of HR-ESI-MS, NMR, and ECD analyses
- Compound 3 exhibited moderate to potent cytotoxicity against A549, HeLa, and SMMC-7721 cells with IC 50 values ranged from 3.69 to 11.84 μM
Metadata-grounded summary
Citation abstract
Two new sesquiterpenoids, flammupin A ( 1 ) and flammupin B ( 2 ), along with two known compounds, enokipodin C ( 3 ) and 5,5'-dibuthoxy-2,2'-bifuran ( 4 ) were obtained from Flammulina velutipes, an endophytic fungus isolated from the roots of Caulophyllum robustum Maxim. The structures were elucidated by the combination of HR-ESI-MS, NMR, and ECD analyses. Compound 3 exhibited moderate to potent cytotoxicity against A549, HeLa, and SMMC-7721 cells with IC 50 values ranged from 3.69 to 11.84 μM.
Citation
Hu JY, Yang T, Liu J, Xiao L, Lin LB, Li YC, et al. (2023). Two new sesquiterpenoids from plant endophytic fungus Flammulina velutipes. Journal of Asian natural products research https://doi.org/10.1080/10286020.2022.2077199 PMID: 35616229
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