Ganonorsterone A, a norsteroid from the medicinal fungus Ganoderma lingzhi.

Metadata-grounded summary

Citation abstract

Phytochemical investigation on the fruiting bodies of the medicinal fungus Ganoderma lingzhi led to the isolation of a new norsteroid, namely ganonorsterone A ( 1 ), together with one known steroid, cyathisterol ( 2 ). The structure and absolute configuration of compound 1 were assigned by extensive analysis of MS, NMR data, and quantum-chemical calculations including electronic circular dichroism (ECD) and calculated 13 C NMR-DP4+ analysis. Bioassay results showed that compound 1 displayed moderate inhibition on NO production in RAW 264.7 macrophages.