Yellow Morel · 2011 · Research Support, Non U.S. Gov'T
Medium relevanceAntioxidant and NF-κB inhibitory constituents isolated from Morchella esculenta.
Morchella esculenta
Key points
- (Morchellaceae) was investigated for its antioxidant activity by measuring the intracellular reactive oxygen species in HT-29 colon cancer cells
- The methylene chloride extract, which showed the highest antioxidant activity, led to the isolation of four fungal sterols, 1-4, and trilinolein (5), in addition to methyl myristate (6), 1-linoleoylglycerol (7), and ceramide (8)
- The isolated compounds were identified through the analysis of various spectroscopic methods
- In the hydroxyl radical assay, 5-dihydroergosterol exhibited significant antioxidant activity
- All compounds isolated were also tested using an enzyme-based Elisa NF-κB assay
- Fungal sterols and trilinolein showed significant inhibition of NF-κB activation in the NF-κB assay
Metadata-grounded summary
Citation abstract
Morchella esculenta Pers. (Morchellaceae) was investigated for its antioxidant activity by measuring the intracellular reactive oxygen species in HT-29 colon cancer cells. The methylene chloride extract, which showed the highest antioxidant activity, led to the isolation of four fungal sterols, 1-4, and trilinolein (5), in addition to methyl myristate (6), 1-linoleoylglycerol (7), and ceramide (8). The isolated compounds were identified through the analysis of various spectroscopic methods. In the hydroxyl radical assay, 5-dihydroergosterol exhibited significant antioxidant activity. All compounds isolated were also tested using an enzyme-based Elisa NF-κB assay. Fungal sterols and trilinolein showed significant inhibition of NF-κB activation in the NF-κB assay.
Citation
Kim JA, Lau E, Tay D, De Blanco EJ (2011). Antioxidant and NF-κB inhibitory constituents isolated from Morchella esculenta. Natural product research https://doi.org/10.1080/14786410802425746 PMID: 20234969
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