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Maitake, Hen of the Woods · 2016 · Research Support, Non U.S. Gov'T

High relevance

Extraction, identification and antimicrobial activity of a new furanone, grifolaone A, from Grifola frondosa.

Grifola frondosa

Immune support
SpeciesMaitake, Hen of the Woods
JournalNatural product research
Year2016

Key points

  • A furanone (1), (S)-methyl 2-(2-hydroxy-3,4-dimethyl-5-oxo-2,5-dihydrofuran-2-yl)acetate, was isolated from the edible mushroom Grifola frondosa
  • Mass spectrometry and NMR analyses were used to elucidate the structure of this compound, and its absolute configuration was determined using circular dichroism spectroscopy
  • Compound 1 exhibited specific antifungal activity against the plant pathogens, Fusarium oxysporum, Gibberella zeae and Piricularia oryzae and the opportunistic human pathogen, Pseudallescheria boydii, resulting in minimum inhibitory concentration values of 2.5, 2.5, 1.25 and 0.15 μg/mL, respectively
  • In contrast, the furanone showed only weak activity towards Aspergillus spp., Candida albicans and several other fungal strains tested as well as no appreciable antibacterial activity

Metadata-grounded summary

Citation abstract

A furanone (1), (S)-methyl 2-(2-hydroxy-3,4-dimethyl-5-oxo-2,5-dihydrofuran-2-yl)acetate, was isolated from the edible mushroom Grifola frondosa. Mass spectrometry and NMR analyses were used to elucidate the structure of this compound, and its absolute configuration was determined using circular dichroism spectroscopy. Compound 1 exhibited specific antifungal activity against the plant pathogens, Fusarium oxysporum, Gibberella zeae and Piricularia oryzae and the opportunistic human pathogen, Pseudallescheria boydii, resulting in minimum inhibitory concentration values of 2.5, 2.5, 1.25 and 0.15 μg/mL, respectively. In contrast, the furanone showed only weak activity towards Aspergillus spp., Candida albicans and several other fungal strains tested as well as no appreciable antibacterial activity.

Citation

He X, Du X, Zang X, Dong L, Gu Z, Cao L, et al. (2016). Extraction, identification and antimicrobial activity of a new furanone, grifolaone A, from Grifola frondosa. Natural product research https://doi.org/10.1080/14786419.2015.1081197 PMID: 26374926

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