Anti-inflammatory activities of the chemical constituents isolated from Trametes versicolor.

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Citation abstract

Twenty-seven compounds including nine triterpenoids ( 1 - 9 ), eight sterols ( 10 - 17 ), two ribonucleotides ( 18, 19 ), four phenols ( 20 - 23 ), three glycosides ( 24 - 26 ), and one furan ( 27 ) were isolated from the fruiting bodies of Trametes versicolor (L.) Lloyd. This study is the first confirmation of the presence of the 11 compounds ( 3, 5, 6, 8, 18, 20, 21, 23 - 25, and 27 ) isolated from the Polyporaceae family, with six of these ( 2 and 12 - 16 ) from the genus Trametes. Compounds 3, 4, 10, 11, 16 and 17 were found to significantly inhibit the production of NO, TNF-α and IL-6 in a dose-dependent manner.