One new sterpurane sesquiterpene from cultures of the basidiomycete Pholiota nameko.

Pholiota microspora

Immune support

SpeciesNameko, Nametake

JournalNatural product research

Year2020

Key points

One new sterpurane sesquiterpene ( 1 ), named (3 R,6 S,7 S,8 R,10 S )-3,7,14-trihydroxy-1-sterpurene was isolated from cultures of the basidiomycete Pholiota nameko
The structure of new compound was elucidated by extensive spectroscopic
Additionally, a single crystal X-ray diffraction not only confirmed the structure, but also determined the absolute configuration of the new compound
The compound was evaluated for cytotoxicity against five human cancer cell lines, but no significant cytotoxicity were found (IC 50 values > 40 μM)

Metadata-grounded summary

Citation abstract

One new sterpurane sesquiterpene ( 1 ), named (3 R,6 S,7 S,8 R,10 S )-3,7,14-trihydroxy-1-sterpurene was isolated from cultures of the basidiomycete Pholiota nameko. The structure of new compound was elucidated by extensive spectroscopic. Additionally, a single crystal X-ray diffraction not only confirmed the structure, but also determined the absolute configuration of the new compound. The compound was evaluated for cytotoxicity against five human cancer cell lines, but no significant cytotoxicity were found (IC 50 values > 40 μM).

Citation

Niu WR, Guo CL, Lou DJ, Li RT, Xiang Q, Zou YL, et al. (2020). One new sterpurane sesquiterpene from cultures of the basidiomycete Pholiota nameko. Natural product research https://doi.org/10.1080/14786419.2019.1586694 PMID: 30887855

Open citation