Reishi, Lingzhi · 2023 · Journal Article
High relevanceNor-triterpenoids from the fruiting bodies of Ganoderma lucidum and their inhibitory activity against FAAH.
Ganoderma lucidum
Key points
- Two new nor-triterpenoids ganodrenol A ( 1 ), B ( 2 ), and a new natural product ganodrenol C ( 3 ), along with three known nor-triterpenoids ( 4 - 6 ) were isolated from the fruiting bodies of Ganoderma lucidum
- The chemical structures of these isolates were determined by 1 D and 2 D NMR, HRESIMS, and X-ray crystallography analysis
- The inhibitory effects of isolated triterpenoids ( 1 - 6 ) against FAAH were evaluated by an in vitro assay, and compound 4 showed an inhibition rate of 70.27%
- In addition, the cytotoxic effect of compounds ( 1 - 6 ) was evaluated against LOVO, MCF-7, and RAW264.7 cells, which displayed no significant cytotoxicity
Metadata-grounded summary
Citation abstract
Two new nor-triterpenoids ganodrenol A ( 1 ), B ( 2 ), and a new natural product ganodrenol C ( 3 ), along with three known nor-triterpenoids ( 4 - 6 ) were isolated from the fruiting bodies of Ganoderma lucidum. The chemical structures of these isolates were determined by 1 D and 2 D NMR, HRESIMS, and X-ray crystallography analysis. The inhibitory effects of isolated triterpenoids ( 1 - 6 ) against FAAH were evaluated by an in vitro assay, and compound 4 showed an inhibition rate of 70.27%. In addition, the cytotoxic effect of compounds ( 1 - 6 ) was evaluated against LOVO, MCF-7, and RAW264.7 cells, which displayed no significant cytotoxicity.
Citation
Li D, Leng Y, Liao Z, Hu J, Sun Y, Deng S, et al. (2023). Nor-triterpenoids from the fruiting bodies of Ganoderma lucidum and their inhibitory activity against FAAH. Natural product research https://doi.org/10.1080/14786419.2022.2078817 PMID: 35608196
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