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Reishi, Lingzhi · 2023 · Journal Article

High relevance

Cytotoxic lanostane-type triterpenes from the fruiting bodies of Ganoderma lucidum.

Ganoderma lucidum

OncologyImmune supportMetabolic healthLiver support
SpeciesReishi, Lingzhi
JournalNatural product research
Year2023

Key points

  • A new lanostane-type triterpene, namely 3-oxo-5α-lanosta-7,9(11)-dien-24-oic acid methyl ester ( 2 ), and three known compounds including ganoderal A ( 1 ), ganoderiol B ( 3 ) and ganodermenonol ( 4 ) were isolated from the fruiting bodies of Ganoderma lucidum by silica gel column chromatography and Sephadex LH-20 column chromatography
  • Their structures were determined by extensive NMR data and mass spectral analysis
  • The in vitro cytotoxic activity of the isolated compounds against SK-Hep-1, HepG2, Hela and Hela/VCR cancer cell lines was assessed by using MTT assay
  • The IC 50 values of compound 1 were 43.09 ± 2.86, 42.31 ± 1.78 and 46.51 ± 1.95 μM in SK-Hep-1, HepG2 and Hela cells, respectively, after 48 h
  • The IC 50 values of compound 4 were 44.70 ± 2.32 and 41.33 ± 2.15 μM in Hela and Hela/VCR cells, respectively, after 48 h

Metadata-grounded summary

Citation abstract

A new lanostane-type triterpene, namely 3-oxo-5α-lanosta-7,9(11)-dien-24-oic acid methyl ester ( 2 ), and three known compounds including ganoderal A ( 1 ), ganoderiol B ( 3 ) and ganodermenonol ( 4 ) were isolated from the fruiting bodies of Ganoderma lucidum by silica gel column chromatography and Sephadex LH-20 column chromatography. Their structures were determined by extensive NMR data and mass spectral analysis. The in vitro cytotoxic activity of the isolated compounds against SK-Hep-1, HepG2, Hela and Hela/VCR cancer cell lines was assessed by using MTT assay. The IC 50 values of compound 1 were 43.09 ± 2.86, 42.31 ± 1.78 and 46.51 ± 1.95 μM in SK-Hep-1, HepG2 and Hela cells, respectively, after 48 h. The IC 50 values of compound 4 were 44.70 ± 2.32 and 41.33 ± 2.15 μM in Hela and Hela/VCR cells, respectively, after 48 h.

Citation

Huang XR, Cai F, Chen J, Wu CH, Li Y, Xu JH, et al. (2023). Cytotoxic lanostane-type triterpenes from the fruiting bodies of Ganoderma lucidum. Natural product research https://doi.org/10.1080/14786419.2022.2146107 PMID: 36382774

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