Lion's Mane, Yamabushitake · 2023 · Journal Article
High relevanceNew benzaldehyde derivatives from the fruiting bodies of Hericium erinaceus with cytotoxic activity.
Hericium erinaceus
Key points
- Four new natural compounds named hericenone O ( 1 ), hericenone P ( 2 ), hericenone Q ( 3 ), and hericenone R ( 4 ), two of them were reported synthetically ( 3 - 4 ), together with eleven known compounds were isolated from the fruiting bodies of Hericium erinaceus
- The chemical structures of the isolated compounds were elucidated by using NMR analysis and mass spectrometry, as well as comparisons with the reported data in the literature
- The bioactivity evaluation revealed that hericenone Q showed significant cytotoxic activity against Hep-G2 with IC 50 values of 23.89 μM, and against HCT-116 with IC 50 values of 65.64 μM
Metadata-grounded summary
Citation abstract
Four new natural compounds named hericenone O ( 1 ), hericenone P ( 2 ), hericenone Q ( 3 ), and hericenone R ( 4 ), two of them were reported synthetically ( 3 - 4 ), together with eleven known compounds were isolated from the fruiting bodies of Hericium erinaceus. The chemical structures of the isolated compounds were elucidated by using NMR analysis and mass spectrometry, as well as comparisons with the reported data in the literature. The bioactivity evaluation revealed that hericenone Q showed significant cytotoxic activity against Hep-G2 with IC 50 values of 23.89 μM, and against HCT-116 with IC 50 values of 65.64 μM.
Citation
Ruan Y, Han C, Wang D, Inoue Y, Amen Y, Othman A, et al. (2023). New benzaldehyde derivatives from the fruiting bodies of Hericium erinaceus with cytotoxic activity. Natural product research https://doi.org/10.1080/14786419.2023.2169687 PMID: 36661112
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