Structurally diverse oxygen-containing aromatic compounds with anti-inflammatory activity from Aspergillus sp. LY-1-2.

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Citation abstract

Three isocoumarins, ascoisocoumarin A ( 1 ), embeurekol ( 2 ), and sclerotinin A ( 3 ), and five biosynthetically related derivatives, ascospinols A-C ( 4, 6, and 7 ), and talaflavuols C and B ( 5 and 8 ), together with twelve polyketides or terpenes ( 9 - 20 ) were isolated from the fungus Aspergillus sp. LY-1-2 inhabited in a sample of Cordyceps sp. Most of them belong to the family of oxygen-containing aromatic compounds and compounds 1, 4, 6, and 7 are previously undescribed compounds. Their planar structures were established by a combined spectroscopic analysis of HRESIMS and NMR, and their stereochemistry was determined by 13 C NMR calculations with sorted training set (STS) protocol analysis, and ECD calculations. New compounds 1 and 6 displayed potential anti-inflammatory effects in lipopolysaccharide (LPS)-induced BV2 microglia cells.