A new sesterterpenoid with β-glucuronidase inhibitory activity from the Cordyceps-colonising fungus Aspergillus versicolour ZJUTE2.

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Abstract

A new sesterterpenoid versicolorin A (1) and five known compounds 2-6 were isolated from a Cordyceps-colonising fungus Aspergillus versicolour ZJUTE2 cultured on soybean meal. The planar structure of 1 was determined by 1D, 2D NMR and HR-ESI-MS. The stereochemistry of 1 was established by NOESY experiment, quantum chemical calculation of 13C NMR combined with DP4+ probability analysis, and comparison of the optical rotations. Compound 1 exhibited comparable in vitro β-glucuronidase inhibitory activity (IC50 = 49.82 ± 1.21 µM) with D-saccharicacid 1,4-lactone (IC50 = 57.35 ± 0.78 µM).