Cordyceps, Caterpillar Fungus · 2025 · Journal Article
Medium relevanceA new sesterterpenoid with β-glucuronidase inhibitory activity from the Cordyceps-colonising fungus Aspergillus versicolour ZJUTE2.
Ophiocordyceps sinensis
Key points
- A new sesterterpenoid versicolorin A ( 1 ) and five known compounds 2 - 6 were isolated from a Cordyceps -colonising fungus Aspergillus versicolour ZJUTE2 cultured on soybean meal
- The planar structure of 1 was determined by 1D, 2D NMR and HR-ESI-MS. The stereochemistry of 1 was established by NOESY experiment, quantum chemical calculation of 13 C NMR combined with DP4+ probability analysis, and comparison of the optical rotations
- Compound 1 exhibited comparable in vitro β -glucuronidase inhibitory activity (IC 50 = 49.82 ± 1.21 µM) with D-saccharicacid 1,4-lactone (IC 50 = 57.35 ± 0.78 µM)
Metadata-grounded summary
Citation abstract
A new sesterterpenoid versicolorin A ( 1 ) and five known compounds 2 - 6 were isolated from a Cordyceps -colonising fungus Aspergillus versicolour ZJUTE2 cultured on soybean meal. The planar structure of 1 was determined by 1D, 2D NMR and HR-ESI-MS. The stereochemistry of 1 was established by NOESY experiment, quantum chemical calculation of 13 C NMR combined with DP4+ probability analysis, and comparison of the optical rotations. Compound 1 exhibited comparable in vitro β -glucuronidase inhibitory activity (IC 50 = 49.82 ± 1.21 µM) with D-saccharicacid 1,4-lactone (IC 50 = 57.35 ± 0.78 µM).
Citation
Ying Y, Qiu Y, Tang J, Lin Y, Xu S, Ni J, et al. (2025). A new sesterterpenoid with β-glucuronidase inhibitory activity from the Cordyceps-colonising fungus Aspergillus versicolour ZJUTE2. Natural product research https://doi.org/10.1080/14786419.2025.2481477 PMID: 40105699
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