Decalin derivatives from an endophytic fungus Trichoderma harzianum GLQ03 and their anti-inflammatory activities.

Ganoderma lucidum

OncologyImmune supportMetabolic healthLiver support

SpeciesReishi, Lingzhi

JournalNatural product research

Year2025

Key points

Eight metabolites ( 1 - 8 ) including a new compound tandyukisin J ( 1 ) were isolated from Trichoderma harzianum GLQ03 isolated from Ganoderma lucidum
Their absolute configurations were determined based on spectroscopic analysis and CD comparison
In this study, specific decalin derivatives (compounds 2, 3, 4, 6, 7, and 8 ) were found to significantly inhibit IL-6/IL-1β expression using RT-qPCR in an LPS-induced RAW264.7 macrophage inflammatory model
These results provide the molecular basis of the anti-inflammatory activity of decalin compounds

Metadata-grounded summary

Citation abstract

Eight metabolites ( 1 - 8 ) including a new compound tandyukisin J ( 1 ) were isolated from Trichoderma harzianum GLQ03 isolated from Ganoderma lucidum. Their absolute configurations were determined based on spectroscopic analysis and CD comparison. In this study, specific decalin derivatives (compounds 2, 3, 4, 6, 7, and 8 ) were found to significantly inhibit IL-6/IL-1β expression using RT-qPCR in an LPS-induced RAW264.7 macrophage inflammatory model. These results provide the molecular basis of the anti-inflammatory activity of decalin compounds.

Citation

Li PS, Chen QY, He JY, Qiu XH, Wang F, Luo Q, et al. (2025). Decalin derivatives from an endophytic fungus Trichoderma harzianum GLQ03 and their anti-inflammatory activities. Natural product research https://doi.org/10.1080/14786419.2025.2509885 PMID: 40424607

Open citation