Reishi, Lingzhi · 2025 · Journal Article
Medium relevanceBioactive secondary metabolites from an endophytic fungus Chloridium virescens GLQ05 and structural revision of alteamide.
Ganoderma lucidum
Key points
- Two previously undescribed metabolites, chlovirescenols A ( 1 ) and B ( 5 ), along with six known compounds including amides ( 2 - 4 ), macrolides ( 6 and 8 ), meroterpenoid ( 7 ), were obtained from the Ganoderma lucidum -derived endophyte Chloridium virescens GLQ05
- Their structural elucidation was achieved through comprehensive spectroscopic analysis
- Besides, the originally proposed structure of alteamide has been revised
- In the LPS-stimulated RAW264.7 macrophage model, chlovirescenols A ( 1 ) and B ( 5 ) significantly suppressed the expression of the TNF-α as quantified with RT-qPCR analysis
Metadata-grounded summary
Citation abstract
Two previously undescribed metabolites, chlovirescenols A ( 1 ) and B ( 5 ), along with six known compounds including amides ( 2 - 4 ), macrolides ( 6 and 8 ), meroterpenoid ( 7 ), were obtained from the Ganoderma lucidum -derived endophyte Chloridium virescens GLQ05. Their structural elucidation was achieved through comprehensive spectroscopic analysis. Besides, the originally proposed structure of alteamide has been revised. In the LPS-stimulated RAW264.7 macrophage model, chlovirescenols A ( 1 ) and B ( 5 ) significantly suppressed the expression of the TNF-α as quantified with RT-qPCR analysis.
Citation
Liu S, Li PT, Li P, Qiu X, Cheng X, Luo Q, et al. (2025). Bioactive secondary metabolites from an endophytic fungus Chloridium virescens GLQ05 and structural revision of alteamide. Natural product research https://doi.org/10.1080/14786419.2025.2580440 PMID: 41186917
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