Anti-Inflammatory Activity of Water-Soluble Polysaccharide of Agaricus blazei Murill on Ovariectomized Osteopenic Rats.

Agaricus blazei

Immune supportLiver support

SpeciesAlmond Mushroom, ABM

JournalEvidence-based complementary and alternative medicine: eCAM

Year2013

Key points

In the present study, we investigated the anti-inflammatory activity of water-soluble polysaccharide of Agaricus blazei Murill (WSP-AbM) on ovariectomized osteopenic rats
The rats were administered orally WSP-AbM (200 mg/kg BW) for 8 weeks
Subsequent serum maleic dialdehyde (MDA) level, total antioxidant status (TAOS), nuclear factor kappa B (NF- κ B) level, polymorphonuclear (PMN) cells level, interleukin-1 β (IL-1 β ) level, inducible nitric oxide synthase (iNOS) level, tumor necrosis factor- α (TNF- α ) level, adhesion molecule (ICAM-1), and cyclooxygenase-2 (COX-2) were determined by enzyme linked immunosorbent assay (ELISA) and immunohistochemistry, respectively
WSP-AbM administration markedly (P < 0.05) decreased serum IL-1 β and TNF- α levels and the expressions of ICAM-1, COX-2, and iNOS NF- κ B compared with OVX rats
WSP-AbM administration alsomarkedly (P < 0.05) decreased PMN infiltration
In conclusion, we observed that WSP-AbM supplementation had anti-inflammatory effects in a model of osteoporosis disease

Metadata-grounded summary

Citation abstract

In the present study, we investigated the anti-inflammatory activity of water-soluble polysaccharide of Agaricus blazei Murill (WSP-AbM) on ovariectomized osteopenic rats. The rats were administered orally WSP-AbM (200 mg/kg BW) for 8 weeks. Subsequent serum maleic dialdehyde (MDA) level, total antioxidant status (TAOS), nuclear factor kappa B (NF- κ B) level, polymorphonuclear (PMN) cells level, interleukin-1 β (IL-1 β ) level, inducible nitric oxide synthase (iNOS) level, tumor necrosis factor- α (TNF- α ) level, adhesion molecule (ICAM-1), and cyclooxygenase-2 (COX-2) were determined by enzyme linked immunosorbent assay (ELISA) and immunohistochemistry, respectively. WSP-AbM administration markedly (P < 0.05) decreased serum IL-1 β and TNF- α levels and the expressions of ICAM-1, COX-2, and iNOS NF- κ B compared with OVX rats. WSP-AbM administration alsomarkedly (P < 0.05) decreased PMN infiltration. In conclusion, we observed that WSP-AbM supplementation had anti-inflammatory effects in a model of osteoporosis disease.

Citation

Wang P, Li XT, Sun L, Shen L (2013). Anti-Inflammatory Activity of Water-Soluble Polysaccharide of Agaricus blazei Murill on Ovariectomized Osteopenic Rats. Evidence-based complementary and alternative medicine: eCAM https://doi.org/10.1155/2013/164817 PMID: 24348690

Open citation