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King Oyster, Eryngii · 2014 · Research Article

High relevance

Pleurotus eryngii Ameliorates Lipopolysaccharide-Induced Lung Inflammation in Mice.

Pleurotus eryngii

Immune supportGut & microbiomeLiver supportRespiratory
SpeciesKing Oyster, Eryngii
JournalEvidence-based complementary and alternative medicine: eCAM
Year2014

Key points

  • Pleurotus eryngii (P. eryngii) is consumed as a fresh cultivated mushroom worldwide and demonstrated to have multiple beneficial effects
  • We investigated the anti-inflammatory effect of P. eryngii in mice with acute lung injury (ALI)
  • Intranasal instillation of lipopolysaccharide (LPS) (10 μ g/site/mouse) induced marked lung inflammation (increase in the number of inflammatory cells, protein leakage, and production of nitric oxide in bronchoalveolar lavage fluid) as well as histopathological damage in the lung, 6 h after treatment
  • Mice administered heat-treated P. eryngii (0.3-1 g/kg, p.o
  • (HTPE)) 1 h before LPS challenge showed decreased pulmonary inflammation and ameliorated histopathological damage
  • These results suggest that HTPE has anti-inflammatory effects against ALI. Thus, P. eryngii itself may also have anti-inflammatory effects and could be a beneficial food for the prevention of ALI induced by bacterial infection

Metadata-grounded summary

Citation abstract

Pleurotus eryngii (P. eryngii) is consumed as a fresh cultivated mushroom worldwide and demonstrated to have multiple beneficial effects. We investigated the anti-inflammatory effect of P. eryngii in mice with acute lung injury (ALI). Intranasal instillation of lipopolysaccharide (LPS) (10 μ g/site/mouse) induced marked lung inflammation (increase in the number of inflammatory cells, protein leakage, and production of nitric oxide in bronchoalveolar lavage fluid) as well as histopathological damage in the lung, 6 h after treatment. Mice administered heat-treated P. eryngii (0.3-1 g/kg, p.o. (HTPE)) 1 h before LPS challenge showed decreased pulmonary inflammation and ameliorated histopathological damage. These results suggest that HTPE has anti-inflammatory effects against ALI. Thus, P. eryngii itself may also have anti-inflammatory effects and could be a beneficial food for the prevention of ALI induced by bacterial infection.

Citation

Kawai J, Andoh T, Ouchi K, Inatomi S (2014). Pleurotus eryngii Ameliorates Lipopolysaccharide-Induced Lung Inflammation in Mice. Evidence-based complementary and alternative medicine: eCAM https://doi.org/10.1155/2014/532389 PMID: 24799939

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