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Chaga · 2014 · Research Article

High relevance

Protective Effect of Polysaccharides from Inonotus obliquus on Streptozotocin-Induced Diabetic Symptoms and Their Potential Mechanisms in Rats.

Inonotus obliquus

Immune supportMetabolic healthLiver supportSkin & hydration
SpeciesChaga
JournalEvidence-based complementary and alternative medicine: eCAM
Year2014

Key points

  • The present study aimed to evaluate the therapeutic effects of polysaccharides from Inonotus obliquus (PIO) on streptozotocin- (STZ-) induced diabetic symptoms and their potential mechanisms
  • The effect of PIO on body weight, blood glucose, damaged pancreatic β-cells, oxidative stresses, proinflammatory cytokines, and glucose metabolizing enzymes in liver was studied
  • The results show that administration of PIO can restore abnormal oxidative indices near normal levels
  • The STZ-damaged pancreatic β-cells of the rats were partly recovered gradually after the mice were administered with PIO 6 weeks later
  • Therefore, we may assume that PIO is effective in the protection of STZ-induced diabetic rats and PIO may be of use as antihyperglycemic agent

Metadata-grounded summary

Citation abstract

The present study aimed to evaluate the therapeutic effects of polysaccharides from Inonotus obliquus (PIO) on streptozotocin- (STZ-) induced diabetic symptoms and their potential mechanisms. The effect of PIO on body weight, blood glucose, damaged pancreatic β-cells, oxidative stresses, proinflammatory cytokines, and glucose metabolizing enzymes in liver was studied. The results show that administration of PIO can restore abnormal oxidative indices near normal levels. The STZ-damaged pancreatic β-cells of the rats were partly recovered gradually after the mice were administered with PIO 6 weeks later. Therefore, we may assume that PIO is effective in the protection of STZ-induced diabetic rats and PIO may be of use as antihyperglycemic agent.

Citation

Diao BZ, Jin WR, Yu XJ (2014). Protective Effect of Polysaccharides from Inonotus obliquus on Streptozotocin-Induced Diabetic Symptoms and Their Potential Mechanisms in Rats. Evidence-based complementary and alternative medicine: eCAM https://doi.org/10.1155/2014/841496 PMID: 25093030

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