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Cordyceps, Caterpillar Fungus · 1989 · Journal Article

Low relevance

The Correlation between Molecular Weight and Antitumor Acitivity of Galactosaminoglycan (CO-N) from Cordyceps ophioglossoides

Ophiocordyceps sinensis

OncologyImmune supportEnergy & fatigue
SpeciesCordyceps, Caterpillar Fungus
JournalChemical and Pharmaceutical Bulletin
Year1989

Key points

  • A galactosaminoglycan (CO-N) obtained by ultrasonication from a protein-bound polysaccharide SN-C, which was isolated from Cordyceps ophioglossoides culture, has a direct cytotoxicity against tumor cells (Ohmori et al., Chem
  • High performance liquid chromatographic analysis revealed that CO-N shows a broad molecular weight distribution with an average molecular weight of 33000
  • A potent antitumor activity of CO-N was observed in the higher-molecular-weight fraction on gel filtration, and the low-molecular-weight fraction below 6600 showed a weak activity
  • However, the depolymerized CO-N (ca. 5500) obtained by further ultrasonication of the original CO-N still retained the antitumor activity of CO-N against Ehrlich ascitic carcinoma or MM46 solid mammary carcinoma

From the paper

Abstract

A galactosaminoglycan (CO-N) obtained by ultrasonication from a protein-bound polysaccharide SN-C, which was isolated from Cordyceps ophioglossoides culture, has a direct cytotoxicity against tumor cells (Ohmori et al., Chem. Pharm. Bull., 37, 1019 (1989). High performance liquid chromatographic analysis revealed that CO-N shows a broad molecular weight distribution with an average molecular weight of 33000. A potent antitumor activity of CO-N was observed in the higher-molecular-weight fraction on gel filtration, and the low-molecular-weight fraction below 6600 showed a weak activity. However, the depolymerized CO-N (ca. 5500) obtained by further ultrasonication of the original CO-N still retained the antitumor activity of CO-N against Ehrlich ascitic carcinoma or MM46 solid mammary carcinoma.

Citation

Toshihiro OHMORI Kohji TAMURA Nobuo OHGANE Tsuyoshi NAKAMURA Gosei KAWANISHI Haruki YAMADA Kikuo NOMOTO (1989). The Correlation between Molecular Weight and Antitumor Acitivity of Galactosaminoglycan (CO-N) from Cordyceps ophioglossoides. Chemical and Pharmaceutical Bulletin https://doi.org/10.1248/cpb.37.1337

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