Maitake, Hen of the Woods · 1989 · Journal Article
Medium relevanceAntitumor and Immunomodulating Activities of a β-Glucan Obtained from Liquid-Cultured Grifola frondosa
Grifola frondosa
Key points
- The effects of the beta-1,3-glucan, LELFD, obtained from liquid-cultured mycelium of Grifola frondosa, on the growth of syngeneic tumors and immune responses in mice were examined
- In Meth A or IMC solid tumor systems, LELFD administered intraperitoneally (i.p.) or intralesionally (i.l.) exhibited significant antitumor effects
- However, the growth of L1210 and P388 leukemias was unaffected by the injection of LELFD. The injection of LELFD i.p. enhanced the activities of natural killer cells and macrophages in mice
- LELFD also enhanced the antibody response when it was injected i.p. with sheep red blood cells into mice
- Furthermore, it was found that LELFD could activate the alternative complement pathway
Metadata-grounded summary
Citation abstract
The effects of the beta-1,3-glucan, LELFD, obtained from liquid-cultured mycelium of Grifola frondosa, on the growth of syngeneic tumors and immune responses in mice were examined. In Meth A or IMC solid tumor systems, LELFD administered intraperitoneally (i.p.) or intralesionally (i.l.) exhibited significant antitumor effects. However, the growth of L1210 and P388 leukemias was unaffected by the injection of LELFD. The injection of LELFD i.p. enhanced the activities of natural killer cells and macrophages in mice. LELFD also enhanced the antibody response when it was injected i.p. with sheep red blood cells into mice. Furthermore, it was found that LELFD could activate the alternative complement pathway.
Citation
Suzuki I, Hashimoto K, Oikawa S, Sato K, Osawa M, Yadomae T (1989). Antitumor and Immunomodulating Activities of a β-Glucan Obtained from Liquid-Cultured Grifola frondosa. Chemical & pharmaceutical bulletin https://doi.org/10.1248/cpb.37.410 PMID: 2743484
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