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Reishi, Lingzhi · 1989 · Journal Article

Low relevance

GANODERIC ACID AND ITS DERIVATIVES AS CHOLESTEROL SYNTHESIS INHIBITORS

Ganoderma lucidum

Energy & fatigueMetabolic healthLiver support
SpeciesReishi, Lingzhi
JournalChemical and Pharmaceutical Bulletin
Year1989

Key points

  • Oxygenated lanosterol derivatives, which were isolated from Ganoderma lucidum (Polyporaceae) or their derivatives obtained by chemical conversion, were tested for their effect on cholesterol biosynthesis from 24,25-dihydrolanosterol by rat hepatic subcellular 10,000 x g supernatant fraction
  • The sterol (VI, 40 microM) with 7-oxo and 15 alpha-hydroxy groups potently inhibited the synthesis of cholesterol from [24,25-3H]-24,25-dihydrolanosterol (18 microM)

From the paper

Abstract

Oxygenated lanosterol derivatives, which were isolated from Ganoderma lucidum (Polyporaceae) or their derivatives obtained by chemical conversion, were tested for their effect on cholesterol biosynthesis from 24,25-dihydrolanosterol by rat hepatic subcellular 10,000 x g supernatant fraction. The sterol (VI, 40 microM) with 7-oxo and 15 alpha-hydroxy groups potently inhibited the synthesis of cholesterol from [24,25-3H]-24,25-dihydrolanosterol (18 microM).

Citation

Yasuo KOMODA Masato SHIMIZU Yoshiko SONODA Yoshihiro SATO (1989). GANODERIC ACID AND ITS DERIVATIVES AS CHOLESTEROL SYNTHESIS INHIBITORS. Chemical and Pharmaceutical Bulletin https://doi.org/10.1248/cpb.37.531

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