Cordycedipeptide A, a New Cyclodipeptide from the Culture Liquid of Cordyceps sinensis (BERK.) SACC.

Ophiocordyceps sinensis

Oncology

SpeciesCordyceps, Caterpillar Fungus

JournalChemical and Pharmaceutical Bulletin

Year2005

Key points

A new cyclodipeptide named as cordycedipeptide A, a new natural compound and two known compound were isolated from the culture liquid of Cordyceps sinensis (BERK.) SACC. Their structures were elucidated as 3-acetamino-6-isobutyl-2,5-dioxopiperazine (1), 3-isopropyl-6-isobutyl-2,5-dioxopiperazine (2) and 3,6-di(4-hydroxy)benzyl-2,5-dioxopiperazine (3) by 1D and 2D-NMR techniques
The cytotoxic assay showed compound 1 had the cytotoxic activities to L-929, A375, and Hela

From the paper

Abstract

A new cyclodipeptide named as cordycedipeptide A, a new natural compound and two known compound were isolated from the culture liquid of Cordyceps sinensis (BERK.) SACC. Their structures were elucidated as 3-acetamino-6-isobutyl-2,5-dioxopiperazine (1), 3-isopropyl-6-isobutyl-2,5-dioxopiperazine (2) and 3,6-di(4-hydroxy)benzyl-2,5-dioxopiperazine (3) by 1D and 2D-NMR techniques. The cytotoxic assay showed compound 1 had the cytotoxic activities to L-929, A375, and Hela.

Citation

Jing-Ming Jia Xiao-Chi Ma Chun-Fu Wu Li-Jun Wu Gao-sheng Hu (2005). Cordycedipeptide A, a New Cyclodipeptide from the Culture Liquid of Cordyceps sinensis (BERK.) SACC. Chemical and Pharmaceutical Bulletin https://doi.org/10.1248/cpb.53.582

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