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Zhu Ling, Umbrella Polypore · 2004 · Comparative Study

Low relevance

An Anti-aldosteronic Diuretic Component (Drain dampness) in Polyporus Sclerotium (猪苓)

Polyporus umbellatus

Immune support
SpeciesZhu Ling, Umbrella Polypore
JournalBiological & pharmaceutical bulletin
Year2004

Key points

  • Polyporus Sclerotium botanically from the Polyporus umbellatus (PERS.) FRIES, was traditionally used for the purpose of promoting diuresis
  • The present study investigated the diuretic effect of ergosta-4,6,8(14),22-tetraen-3-one (ergone) which is a maker component according to the chemical assay for its quality standardization
  • It resulted in a reversion to ordinary value of the urinary ratio of Na/K in deoxycoricosterone acetate (DOCA)-treated and adrenalectomized rats, although it had no this effect on the Na or K contents as well as Na/K value both in normal rats and in adrenalectomized rats without DOCA. These data indicate that ergone possesses an anti-aldosteronic diuretic effect
  • Moreover, it was identified in the blood and bile of rats after its administration to the gastrointestinal tract
  • The above results demonstrate that it is an active component of Polyporus Sclerotium

Metadata-grounded summary

Citation abstract

Polyporus Sclerotium botanically from the Polyporus umbellatus (PERS.) FRIES, was traditionally used for the purpose of promoting diuresis. The present study investigated the diuretic effect of ergosta-4,6,8(14),22-tetraen-3-one (ergone) which is a maker component according to the chemical assay for its quality standardization. It resulted in a reversion to ordinary value of the urinary ratio of Na/K in deoxycoricosterone acetate (DOCA)-treated and adrenalectomized rats, although it had no this effect on the Na or K contents as well as Na/K value both in normal rats and in adrenalectomized rats without DOCA. These data indicate that ergone possesses an anti-aldosteronic diuretic effect. Moreover, it was identified in the blood and bile of rats after its administration to the gastrointestinal tract. The above results demonstrate that it is an active component of Polyporus Sclerotium.

Citation

Yuan D, Mori J, Komatsu KI, Makino T, Kano Y (2004). An Anti-aldosteronic Diuretic Component (Drain dampness) in Polyporus Sclerotium (猪苓). Biological & pharmaceutical bulletin https://doi.org/10.1248/bpb.27.867 PMID: 15187435

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