Reishi, Lingzhi · 2006 · Journal Article
Medium relevance5α-Reductase Inhibitory Effect of Triterpenoids Isolated from Ganoderma lucidum
Ganoderma lucidum
Key points
- 5alpha-Reductase inhibitory activity-guided fractionation of the EtOH extract of the fruiting body of Ganoderma lucidum (LEYSS.:FR.) KARST. (Ganodermataceae), which is called Reishi, or Mannentake in Japan and Lingzhi in China, led to the isolation of two active compounds which were ganoderic acid DM and 5alpha-lanosta-7,9(11),24-triene-15alpha,26-dihydroxy-3-one with an IC(50) of 10.6 microM and 41.9 microM respectively
- A carboxyl group of side chain of ganoderic acid DM is essential to elicit the inhibitory activity because of much less activity of its methyl ester
From the paper
Abstract
5alpha-Reductase inhibitory activity-guided fractionation of the EtOH extract of the fruiting body of Ganoderma lucidum (LEYSS.:FR.) KARST. (Ganodermataceae), which is called Reishi, or Mannentake in Japan and Lingzhi in China, led to the isolation of two active compounds which were ganoderic acid DM and 5alpha-lanosta-7,9(11),24-triene-15alpha,26-dihydroxy-3-one with an IC(50) of 10.6 microM and 41.9 microM respectively. A carboxyl group of side chain of ganoderic acid DM is essential to elicit the inhibitory activity because of much less activity of its methyl ester.
Citation
Jie Liu Kenji Kurashiki Kuniyoshi Shimizu Ryuichiro Kondo (2006). 5α-Reductase Inhibitory Effect of Triterpenoids Isolated from Ganoderma lucidum. Biological and Pharmaceutical Bulletin https://doi.org/10.1248/bpb.29.392
Open citation