Maitake, Hen of the Woods · 1985 · Journal Article
Medium relevanceEffect of a polysaccharide fraction from Grifola frondosa on immune response in mice.
Grifola frondosa
Key points
- The biological and immunomodulating activities of polysaccharide fraction (GF-1), an antitumor poysaccharide fraction from cultured fruiting bodies of Grifola frondosa, was examined in mice
- GF-1 showed no cytocidal effect on culturing tumor cells
- However, GF-1 induced resistance against Sarcoma 180 in ICR mice which had completely regressed from the tumor by the effect of GF-1
- The administration of GF-1 into mice increased the weights or cell numbers of spleen, and peritoneal cavity
- GF-1 enhanced the antigen specific antibody response and carbon clearance activity, whereas GF-1 did not show polyclonal B cell activation and mitogenic activities, and the effect on delayed type hypersensitivity
Metadata-grounded summary
Citation abstract
The biological and immunomodulating activities of polysaccharide fraction (GF-1), an antitumor poysaccharide fraction from cultured fruiting bodies of Grifola frondosa, was examined in mice. GF-1 showed no cytocidal effect on culturing tumor cells. However, GF-1 induced resistance against Sarcoma 180 in ICR mice which had completely regressed from the tumor by the effect of GF-1. The administration of GF-1 into mice increased the weights or cell numbers of spleen, and peritoneal cavity. GF-1 enhanced the antigen specific antibody response and carbon clearance activity, whereas GF-1 did not show polyclonal B cell activation and mitogenic activities, and the effect on delayed type hypersensitivity.
Citation
Suzuki I, Itani T, Ohno N, Oikawa S, Sato K, Miyazaki T, et al. (1985). Effect of a polysaccharide fraction from Grifola frondosa on immune response in mice. Journal of pharmacobio-dynamics https://doi.org/10.1248/bpb1978.8.217 PMID: 3891963
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