Maitake, Hen of the Woods · 2002 · Journal Article
High relevanceA Polysaccharide, Extract From Grifola frondosa, Induces Th-1 Dominant Responses in Carcinoma-Bearing BALB/c Mice
Grifola frondosa
Key points
- A polysaccharide, designated as the D-fraction, extracted from maitake (Grifola frondosa), was reported to have anti-tumor effects by activating macrophages and T cells in C3H/HeN mice in which a Th-1 dominant response was established
- In this study using BALB/c mice in which a Th-2 response is genetically dominant, D-fraction reduced the expression of Th-2 cytokine interleukin (IL)-4 but markedly increased the expression of Th-1 cytokine interferon (IFN)-gamma in CD4(+) T cells and also increased IL-12p70 production as well as IFN-gamma production by antigen-presenting cells (APCs), suggesting that D-fraction promotes the differentiation into Th-1 cells of CD4(+) T cells through enhancement of IL-12p70 production by APCs
Metadata-grounded summary
Citation abstract
A polysaccharide, designated as the D-fraction, extracted from maitake (Grifola frondosa), was reported to have anti-tumor effects by activating macrophages and T cells in C3H/HeN mice in which a Th-1 dominant response was established. In this study using BALB/c mice in which a Th-2 response is genetically dominant, D-fraction reduced the expression of Th-2 cytokine interleukin (IL)-4 but markedly increased the expression of Th-1 cytokine interferon (IFN)-gamma in CD4(+) T cells and also increased IL-12p70 production as well as IFN-gamma production by antigen-presenting cells (APCs), suggesting that D-fraction promotes the differentiation into Th-1 cells of CD4(+) T cells through enhancement of IL-12p70 production by APCs.
Citation
Kodama N, Harada N, Nanba H (2002). A Polysaccharide, Extract From Grifola frondosa, Induces Th-1 Dominant Responses in Carcinoma-Bearing BALB/c Mice. Japanese journal of pharmacology https://doi.org/10.1254/jjp.90.357 PMID: 12501013
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