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Lion's Mane, Yamabushitake · 2003 · Research Support, Non U.S. Gov'T

Medium relevance

Hypolipidemic Effect of an Exo-biopolymer Produced from a Submerged Mycelial Culture of Hericium erinaceus

Hericium erinaceus

Metabolic healthLiver support
SpeciesLion's Mane, Yamabushitake
JournalBioscience, biotechnology, and biochemistry
Year2003

Key points

  • The hypolipidemic effect of an exo-biopolymer produced from a submerged mycelial culture of Hericium erinaceus was investigated in dietary-induced hyperlipidemic rats
  • Hypolipidemic effects were proportionally increased with the increasing concentration of the exo-biopolymer for oral administration
  • The exo-biopolymer, at the dose of 200 mg/kg body weight, substantially reduced the plasma total cholesterol (32.9%), LDL cholesterol (45.4%), triglyceride (34.3%), phospholipid (18.9%), atherogenic index (58.7%), and hepatic HMG-CoA reductase activity (20.2%)
  • It increased the plasma HDL cholesterol level (31.1%) as compared to the control group
  • The molecular mass of this exo-biopolymer measured by HPLC was under 40 kDa
  • Total sugar and protein contents were 91.2 and 8.8%, respectively

From the paper

Abstract

The hypolipidemic effect of an exo-biopolymer produced from a submerged mycelial culture of Hericium erinaceus was investigated in dietary-induced hyperlipidemic rats. Hypolipidemic effects were proportionally increased with the increasing concentration of the exo-biopolymer for oral administration. The exo-biopolymer, at the dose of 200 mg/kg body weight, substantially reduced the plasma total cholesterol (32.9%), LDL cholesterol (45.4%), triglyceride (34.3%), phospholipid (18.9%), atherogenic index (58.7%), and hepatic HMG-CoA reductase activity (20.2%). It increased the plasma HDL cholesterol level (31.1%) as compared to the control group. The molecular mass of this exo-biopolymer measured by HPLC was under 40 kDa. Total sugar and protein contents were 91.2 and 8.8%, respectively. The sugar and amino acid compositions of the exo-biopolymer were analyzed in detail.

Citation

Yang BK, Park JB, Song CH (2003). Hypolipidemic Effect of an Exo-biopolymer Produced from a Submerged Mycelial Culture of Hericium erinaceus. Bioscience, biotechnology, and biochemistry https://doi.org/10.1271/bbb.67.1292 PMID: 12843656

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