Fractionation and Anti-tumor Activity of the Mycelia of Liquid-cultured Phellinus linteus

Phellinus linteus

Oncology

SpeciesMesima, Sanghwang

JournalBioscience, biotechnology, and biochemistry

Year2004

Key points

All the fractions of Phellinus linteus mycelia showed anti-tumor activity toward solid tumors planted in mice
The highest anti-tumor activity of 81.2% was observed in the protein-glucan complex obtained by precipitating the 24% NaOH extract at pH 6.0
This protein-glucan complex consisted of 39.3% polysaccharide and 49.4% protein
Its (13)C- and (1)H-NMR data showed that the main glucan part of the complex was simple alpha-1,3-glucan chains

Metadata-grounded summary

Citation abstract

All the fractions of Phellinus linteus mycelia showed anti-tumor activity toward solid tumors planted in mice. The highest anti-tumor activity of 81.2% was observed in the protein-glucan complex obtained by precipitating the 24% NaOH extract at pH 6.0. This protein-glucan complex consisted of 39.3% polysaccharide and 49.4% protein. Its (13)C- and (1)H-NMR data showed that the main glucan part of the complex was simple alpha-1,3-glucan chains.

Citation

Nakamura T, Matsugo S, Uzuka Y, Matsuo S, Kawagishi H (2004). Fractionation and Anti-tumor Activity of the Mycelia of Liquid-cultured Phellinus linteus. Bioscience, biotechnology, and biochemistry https://doi.org/10.1271/bbb.68.868 PMID: 15118316

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