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Almond Mushroom, ABM · 2005 · Journal Article

Medium relevance

In Vitro Augmentation of Natural Killer Activity and Interferon-γ Production in Murine Spleen Cells with Agaricus blazei Fruiting Body Fractions

Agaricus blazei

Immune support
SpeciesAlmond Mushroom, ABM
JournalBioscience, Biotechnology, and Biochemistry
Year2005

Key points

  • Aqueous extracts of the Agaricus blazei fruiting body prepared at different temperatures were fractionated by ethanol precipitation with various ethanol concentrations
  • The original aqueous extracts of A. blazei failed to stimulate natural killer (NK) cell activity in murine spleen cells in vitro, but the strongest effect was observed in a 30% ethanol-soluble-50% ethanol-insoluble fraction prepared from the extract at 40 degrees C (fraction A-50)
  • Fraction A-50 also showed the strongest augmenting effect on interferon (IFN)-gamma production
  • This augmentation of NK activity and IFN-gamma production by fraction A-50 was completely abrogated by a heat treatment

From the paper

Abstract

Aqueous extracts of the Agaricus blazei fruiting body prepared at different temperatures were fractionated by ethanol precipitation with various ethanol concentrations. The original aqueous extracts of A. blazei failed to stimulate natural killer (NK) cell activity in murine spleen cells in vitro, but the strongest effect was observed in a 30% ethanol-soluble-50% ethanol-insoluble fraction prepared from the extract at 40 degrees C (fraction A-50). Fraction A-50 also showed the strongest augmenting effect on interferon (IFN)-gamma production. This augmentation of NK activity and IFN-gamma production by fraction A-50 was completely abrogated by a heat treatment.

Citation

Ming ZHONG Akihiro TAI Itaru YAMAMOTO (2005). In Vitro Augmentation of Natural Killer Activity and Interferon-γ Production in Murine Spleen Cells with Agaricus blazei Fruiting Body Fractions. Bioscience, Biotechnology, and Biochemistry https://doi.org/10.1271/bbb.69.2466

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