Almond Mushroom, ABM · 2008 · Journal Article
Low relevanceInhibitory Effect of Agaricu blazei Murill Components on Abnormal Collagen Fiber Formation in Human Hepatocarcinoma Cells
Agaricus blazei
Key points
- Hot-water extracts of the mycelial culture and fruiting bodies of Agaricus blazei Murill were fractionated by ethanol precipitation, using various ethanol concentrations
- The mycelial fraction (A-4) inhibited abnormal collagen fiber formation, and fractions A-1 to A-3 showed a small inhibitory effect
- The strongest inhibition was obtained by fraction A-4, and no significant inhibition was observed with fractions A-5 and A-6
- With the fruiting bodies, fractions B-1 to B-6 showed no inhibitory effects on collagen fiber formation in HCC. The reverse transcription-polymerase chain reaction (RT-PCR) demonstrates that Agaricus blazei mycelial fraction A-4 did not inhibit the type I, II or III procollagen gene expression
From the paper
Abstract
Hot-water extracts of the mycelial culture and fruiting bodies of Agaricus blazei Murill were fractionated by ethanol precipitation, using various ethanol concentrations. The mycelial fraction (A-4) inhibited abnormal collagen fiber formation, and fractions A-1 to A-3 showed a small inhibitory effect. The strongest inhibition was obtained by fraction A-4, and no significant inhibition was observed with fractions A-5 and A-6. With the fruiting bodies, fractions B-1 to B-6 showed no inhibitory effects on collagen fiber formation in HCC. The reverse transcription-polymerase chain reaction (RT-PCR) demonstrates that Agaricus blazei mycelial fraction A-4 did not inhibit the type I, II or III procollagen gene expression.
Citation
Kenji SORIMACHI Kazumi AKIMOTO Takashi KOGE (2008). Inhibitory Effect of Agaricu blazei Murill Components on Abnormal Collagen Fiber Formation in Human Hepatocarcinoma Cells. Bioscience, Biotechnology, and Biochemistry https://doi.org/10.1271/bbb.70700
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