Different Suppressive Effects of Fucoidan and Lentinan on IL-8 mRNA Expression in in Vitro Gut Inflammation

Lentinula edodes

OncologyImmune supportGut & microbiome

SpeciesShiitake, Hua Gu

JournalBioscience, Biotechnology, and Biochemistry

Year2009

Key points

A system for assessing the anti-inflammatory effects of food factors was developed by establishing a co-culture system with intestinal epithelial Caco-2 cells and macrophage RAW264.7 cells
The results indicate that fucoidan and lentinan exhibited different suppressive effects on interleukin-8 (IL-8) mRNA expression in Caco-2 through tumor necrosis factor-alpha (TNF-alpha) production from RAW264.7 stimulated with lipopolysaccharide (LPS)

From the paper

Abstract

A system for assessing the anti-inflammatory effects of food factors was developed by establishing a co-culture system with intestinal epithelial Caco-2 cells and macrophage RAW264.7 cells. The results indicate that fucoidan and lentinan exhibited different suppressive effects on interleukin-8 (IL-8) mRNA expression in Caco-2 through tumor necrosis factor-alpha (TNF-alpha) production from RAW264.7 stimulated with lipopolysaccharide (LPS).

Citation

Masashi MIZUNO Yosuke NISHITANI Takashi HASHIMOTO Kazuki KANAZAWA (2009). Different Suppressive Effects of Fucoidan and Lentinan on IL-8 mRNA Expression in in Vitro Gut Inflammation. Bioscience, Biotechnology, and Biochemistry https://doi.org/10.1271/bbb.90326

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