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Almond Mushroom, ABM · 2025 · Research Article

Medium relevance

Optimal control of agent-based models via surrogate modeling.

Agaricus blazei

Immune support
SpeciesAlmond Mushroom, ABM
JournalPLoS computational biology
Year2025

Key points

  • This paper describes and validates an algorithm to solve optimal control problems for agent-based models (ABMs)
  • For a given ABM and a given optimal control problem, the algorithm derives a surrogate model, typically lower-dimensional, in the form of a system of ordinary differential equations (ODEs), solves the control problem for the surrogate model, and then transfers the solution back to the original ABM. It applies to quite general ABMs and offers several options for the ODE structure, depending on what information about the ABM is to be used
  • There is a broad range of applications for such an algorithm, since ABMs are used widely in the life sciences, such as ecology, epidemiology, and biomedicine and healthcare, areas where optimal control is an important purpose for modeling, such as for medical digital twin technology

Metadata-grounded summary

Citation abstract

This paper describes and validates an algorithm to solve optimal control problems for agent-based models (ABMs). For a given ABM and a given optimal control problem, the algorithm derives a surrogate model, typically lower-dimensional, in the form of a system of ordinary differential equations (ODEs), solves the control problem for the surrogate model, and then transfers the solution back to the original ABM. It applies to quite general ABMs and offers several options for the ODE structure, depending on what information about the ABM is to be used. There is a broad range of applications for such an algorithm, since ABMs are used widely in the life sciences, such as ecology, epidemiology, and biomedicine and healthcare, areas where optimal control is an important purpose for modeling, such as for medical digital twin technology.

Citation

Fonseca LL, Böttcher L, Mehrad B, Laubenbacher RC (2025). Optimal control of agent-based models via surrogate modeling. PLoS computational biology https://doi.org/10.1371/journal.pcbi.1012138 PMID: 39808665

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