Effects of Polysaccharide from Hericium Erinaceus on Diarrhea Rats Induced by Lincomycin Hydrochloride: A Potential Treatment for Gut Microbiota Dysbiosis

From the paper

Abstract

Abstract In China, the fungus Hericium erinaceus is known as a healthy food crop which possesses digestive tract protection functionality. This research was focus on the effects of polysaccharides extracted from Hericium erinaceus (WHP) on rats with diarrhea induced by antibiotic, specifically on the shifts of gut microbiota. WHP was mainly composed of glucose (88.6%), galactose (9.1%), and fructose (2.3%). It decreased the disease activity index, structure damage of the colon in rats with AAD; increased butyrate production, and affected the gut microbiota through increase the relative abundance of Lactobacillus and Butyricicoccus, while decreased that of Allobaculum and Enterococcus, which closely related to the gut microbiota dysbiosis. It could concluded from this study that WHP can ameliorate antibiotic induced diarrhea by causing the recovery of the colon damage, improving the gut microbiota dysbiosis, and promoting the butyrate production. The results of this study can provide valuable data on how Hericium erinaceus polysaccharide alleviate the damage associated to the intake of antibiotics.