Novel Biosynthesis and Evaluation Cytotoxic Effect of Tellurium Nano-Particle on Breast Cancer Using Co-Culture of Spirulina and Lentinula Edodes

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Abstract

Abstract Introduction Bio-based nanoparticle production has been an alternative method for preparing nanoparticles for pharmaceutical and biomedical applications. This study aims to evaluate the production of tellurium nanoparticles (TeNPs) using the co-culture of algae and fungi and finally to investigate the cytotoxicity of nanoparticles on cancer cell lines MDA-MB-468 and healthy cell line HFF. Methods The production of TeNPs was done using the co-culture of algae and fungi. Using the Tyndall effect, FTIR, and FESEM, nanoparticles were evaluated. Finally, using the MTT assay, the toxicity of the nanoparticles produced on MDA-MB-468 and HFF was investigated. Results Data showed that it is possible to produce TeNPs using the co-cultivation of algae and fungi. Also, the produced nanoparticles had a size between 20 and 30 nm. Examining the cytotoxicity effects of the created nanoparticle showed that this nanoparticle has an inhibitory effect on cancer cells, while it does not affect healthy cells. Conclusion In this study, biosynthesis of TeNPs using co-culture was performed for the first time. The data showed that it is possible to use the co-culture of algae and fungi to produce TeNPs that can inhibit the growth of human breast cancer cells.