Post-Marketing Surveillance of Cordyceps Products in Thailand

From the paper

Abstract

Abstract Background The outbreak of acute kidney injury linked to Cordyceps products in Thailand prompted an assessment of their quality. The aims of this study were to identify the Cordyceps species contained in the dietary supplement and to evaluate legal compliance. Methods A survey and experimental studies were conducted, focusing on oral Cordyceps products selected through convenience sampling. Chemical and microscopic examinations were performed, and thin-layer chromatography was used to identify cordycepin and adenosine in the products. Steroid test kits were employed to detect corticosteroid adulteration. The products’ registration number and advertising approvals by the Thai FDA were verified. Results Sixty-five products were included in the study. The prevalence of products containing cordycepin and C. militaris was 53.8%. Among the products, 11% were unregistered, and 6.2% were adulterated with corticosteroids. 54.3% were mislabeled regarding the substitute or absence of the labeled species and the form of Cordyceps. The prevalence of products with legally compliant physical labeling was 78.5%. However, 72.3% of the products made disease claims through social media. Conclusions The study highlights that the regulation of dietary supplements containing Cordyceps in Thailand does not fully comply with legal standards. Therefore, the public should be aware of these issues with Cordyceps products. The Thai FDA should enhance its post-market surveillance system for health products to better protect consumers.