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Maitake, Hen of the Woods · 2008 · Journal Article

High relevance

Bioactive Substance from Grifola frondosa (Maitake) Mushroom Inhibits CCAAT Enhancer Binding Protein β and δ Expression on C3H10T1/2 B2C1 Adipocyte Cells

Grifola frondosa

Immune support
SpeciesMaitake, Hen of the Woods
JournalJournal of nutritional science and vitaminology
Year2008

Key points

  • Bioactive compound substances from Grifola frondosa (maitake) inhibited adipocyte differentiation of B(2)C(1) preadipocytes
  • This compound is not related to MAP kinase (ERK1 and ERK2) cascades or beta-catenin, which inhibit the expression of Glut4, PPARgamma and C/EBPalpha
  • The compound reduced the expression time of C/EBPbeta and C/EBPdelta
  • These results suggest that the inhibitory action of these bioactive compounds on adipocyte differentiation is exhibited through preadipocytes
  • They cannot induce the expression of PPARgamma or C/EBPalpha because of the reduced expression time of C/EBPbeta and C/EBPdelta

Metadata-grounded summary

Citation abstract

Bioactive compound substances from Grifola frondosa (maitake) inhibited adipocyte differentiation of B(2)C(1) preadipocytes. This compound is not related to MAP kinase (ERK1 and ERK2) cascades or beta-catenin, which inhibit the expression of Glut4, PPARgamma and C/EBPalpha. The compound reduced the expression time of C/EBPbeta and C/EBPdelta. These results suggest that the inhibitory action of these bioactive compounds on adipocyte differentiation is exhibited through preadipocytes. They cannot induce the expression of PPARgamma or C/EBPalpha because of the reduced expression time of C/EBPbeta and C/EBPdelta.

Citation

Minamino K, Yanaga Y, Ohtsuru M (2008). Bioactive Substance from Grifola frondosa (Maitake) Mushroom Inhibits CCAAT Enhancer Binding Protein β and δ Expression on C3H10T1/2 B2C1 Adipocyte Cells. Journal of nutritional science and vitaminology https://doi.org/10.3177/jnsv.54.250 PMID: 18635913

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