Maitake, Hen of the Woods · 2010 · Journal Article
Low relevanceAnti-fungal Cell Wall β-glucan Antibody in Animal Sera
Grifola frondosa
Key points
- beta-Glucan is a major component of the cell walls and pathogen-associated microbial patterns of fungi
- We previously reported the presence of an antibody which reacts to beta-glucan, anti-beta-glucan (BG) antibody, in human sera
- In livestock and domestic pets, the antibody's response to fungal cell wall beta-glucan is little understood
- In this study, we examined the existence and reactivity of anti-BG antibody in various animal species
- We demonstrated the presence of the anti-BG antibody in each animal's serum
- This suggested that the anti-BG antibody interacted with fungal cell wall beta-glucan and participated in the immune-response to pathogenic fungi
Metadata-grounded summary
Citation abstract
beta-Glucan is a major component of the cell walls and pathogen-associated microbial patterns of fungi. We previously reported the presence of an antibody which reacts to beta-glucan, anti-beta-glucan (BG) antibody, in human sera. In livestock and domestic pets, the antibody's response to fungal cell wall beta-glucan is little understood. In this study, we examined the existence and reactivity of anti-BG antibody in various animal species. We demonstrated the presence of the anti-BG antibody in each animal's serum. Individual differences in the titer existed. The antibody was highly reactive to Candida solubilized cell wall beta-glucan (CSBG) while reacting little to grifolan (GRN) from Grifola frondosa. This suggested that the anti-BG antibody interacted with fungal cell wall beta-glucan and participated in the immune-response to pathogenic fungi.
Citation
Ishibashi K, Dogasaki C, Motoi M, Miura N, Adachi Y, Ohno N (2010). Anti-fungal Cell Wall β-glucan Antibody in Animal Sera. Nihon Ishinkin Gakkai zasshi = Japanese journal of medical mycology https://doi.org/10.3314/jjmm.51.99 PMID: 20467198
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