Meroterpenoid Dimers from Ganoderma Mushrooms and Their Biological Activities Against Triple Negative Breast Cancer Cells.

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Citation abstract

(±)-Dimercochlearlactones A-J ( 1 - 10 ), ten pairs of novel meroterpenoid dimers and one known spirocochlealactone A ( 11 ), were isolated from Ganoderma mushrooms. The structural elucidation of new compounds, including their absolute configurations, depends on spectroscopic analysis and electronic circular dichroism (ECD) calculations. Biological studies showed that (+)- and (-)- 2, (-)- 3, and (+)- and (-)- 11 are cytotoxic toward human triple negative breast cancer (TNBC) cells (MDA-MB-231) with IC 50 values of 28.18, 25.65, 11.16, 8.18, and 13.02 μM, respectively. Wound healing assay revealed that five pairs of meroterpenoids (±)- 5 -(±)- 8 and (±)- 10 could significantly inhibit cell mobility at 20 μM in MDA-MB-231 cells. The results provide a new insight into the biological role of Ganoderma meroterpenoids in TNBC.