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Cordyceps, Caterpillar Fungus · 2026 · Research Article

Medium relevance

New Pyridinone Alkaloid and Polyketide from the Cordyceps-Colonizing Fungus Pseudogymnoascus roseus.

Ophiocordyceps sinensis

Energy & fatigueGut & microbiomeRespiratory
SpeciesCordyceps, Caterpillar Fungus
JournalBiomolecules
Year2026

Key points

  • One new pyridinone alkaloid pseudogymnone A ( 1 ) and one new tricyclic polyketide penijanthinone C ( 2 ), together with six known compounds, harzianic acid ( 3 ), 3-methyl-2-(2-nonenyl)-4(1 H )-quinolinone ( 4 ), emodic acid ( 5 ), alaternin ( 6 ), violaceol-I ( 7 ), and violaceol-II ( 8 ), were obtained from the Cordyceps -colonizing fungus Pseudogymnoascus roseus
  • The structures and absolute configurations of the isolated compounds were elucidated through a combination of NMR and MS spectroscopic analyses, ECD calculations, and X-ray crystallography
  • Compound 3 exhibited obvious cytotoxicity against A549 (IC 50 = 4.2 µM) and MGC (IC 50 = 3.8 µM) cell lines
  • Integrated network pharmacology and molecular docking analyses indicated that compound 3 exerts potential anti-gastric-cancer effects by modulating multiple cancer-related signaling pathways, with EGFR identified as a potential target of compound 3

Metadata-grounded summary

Citation abstract

One new pyridinone alkaloid pseudogymnone A ( 1 ) and one new tricyclic polyketide penijanthinone C ( 2 ), together with six known compounds, harzianic acid ( 3 ), 3-methyl-2-(2-nonenyl)-4(1 H )-quinolinone ( 4 ), emodic acid ( 5 ), alaternin ( 6 ), violaceol-I ( 7 ), and violaceol-II ( 8 ), were obtained from the Cordyceps -colonizing fungus Pseudogymnoascus roseus. The structures and absolute configurations of the isolated compounds were elucidated through a combination of NMR and MS spectroscopic analyses, ECD calculations, and X-ray crystallography. Compound 3 exhibited obvious cytotoxicity against A549 (IC 50 = 4.2 µM) and MGC (IC 50 = 3.8 µM) cell lines. Integrated network pharmacology and molecular docking analyses indicated that compound 3 exerts potential anti-gastric-cancer effects by modulating multiple cancer-related signaling pathways, with EGFR identified as a potential target of compound 3.

Citation

Lin J, Guo Y, Wang J, Wang F, Liu L (2026). New Pyridinone Alkaloid and Polyketide from the Cordyceps-Colonizing Fungus Pseudogymnoascus roseus. Biomolecules https://doi.org/10.3390/biom16020187 PMID: 41750258

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