King Oyster, Eryngii · 2017 · Research Article
High relevanceErgostane-Type Sterols from King Trumpet Mushroom (Pleurotus eryngii) and Their Inhibitory Effects on Aromatase.
Pleurotus eryngii
Key points
- Two new ergostane-type sterols; (22E)-5α,6α-epoxyergosta-8,14,22-triene-3β,7β-diol (1) and 5α,6α-epoxyergost-8(14)-ene-3β,7α-diol (2) were isolated from the fruiting bodies of king trumpet mushroom (Pleurotus eryngii), along with eight known compounds (3-10)
- All isolated compounds were evaluated for their inhibitory effects on aromatase
- Among them, 4 and 6 exhibited comparable aromatase inhibitory activities to aminoglutethimide
From the paper
Abstract
Two new ergostane-type sterols; (22E)-5α,6α-epoxyergosta-8,14,22-triene-3β,7β-diol (1) and 5α,6α-epoxyergost-8(14)-ene-3β,7α-diol (2) were isolated from the fruiting bodies of king trumpet mushroom (Pleurotus eryngii), along with eight known compounds (3-10). All isolated compounds were evaluated for their inhibitory effects on aromatase. Among them, 4 and 6 exhibited comparable aromatase inhibitory activities to aminoglutethimide.
Citation
Kikuchi T, Motoyashiki N, Yamada T, Shibatani K, Ninomiya K, Morikawa T, et al. (2017). Ergostane-Type Sterols from King Trumpet Mushroom (Pleurotus eryngii) and Their Inhibitory Effects on Aromatase. International journal of molecular sciences https://doi.org/10.3390/ijms18112479 PMID: 29160820
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