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Turkey Tail, Yun Zhi · 2016 · Research Article

High relevance

In Vitro Antileishmanial Activity of Sterols from Trametes versicolor (Bres. Rivarden).

Trametes versicolor

OncologyImmune support
SpeciesTurkey Tail, Yun Zhi
JournalMolecules (Basel, Switzerland)
Year2016

Key points

  • Two ergostanes, 5α,8α-epidioxy-22E-ergosta-6,22-dien-3β-ol (1) and 5α-ergost-7,22-dien-3β-ol (2), and a lanostane, 3β-hydroxylanostan-8,24-diene-21-oic acid (trametenolic acid) (3), were isolated from an n-hexane extract prepared from the fruiting body of Trametes versicolor (Bres
  • The activity of the isolated sterols was evaluated against promastigotes and amastigotes of Leishmania amazonensis Lainson and Shaw, 1972
  • The lanostane, compound (3), showed the best inhibitory response (IC50 promastigotes 2.9 ± 0.1 μM and IC50 amastigotes 1.6 ± 0.1 μM)
  • This effect was 25-fold higher compared with its cytotoxic effect on peritoneal macrophages from BALB/c mice
  • Therefore, trametenolic acid could be regarded as a promising lead for the synthesis of compounds with antileishmanial activity

Metadata-grounded summary

Citation abstract

Two ergostanes, 5α,8α-epidioxy-22E-ergosta-6,22-dien-3β-ol (1) and 5α-ergost-7,22-dien-3β-ol (2), and a lanostane, 3β-hydroxylanostan-8,24-diene-21-oic acid (trametenolic acid) (3), were isolated from an n-hexane extract prepared from the fruiting body of Trametes versicolor (Bres. Rivarden). The activity of the isolated sterols was evaluated against promastigotes and amastigotes of Leishmania amazonensis Lainson and Shaw, 1972. The lanostane, compound (3), showed the best inhibitory response (IC50 promastigotes 2.9 ± 0.1 μM and IC50 amastigotes 1.6 ± 0.1 μM). This effect was 25-fold higher compared with its cytotoxic effect on peritoneal macrophages from BALB/c mice. Therefore, trametenolic acid could be regarded as a promising lead for the synthesis of compounds with antileishmanial activity.

Citation

Leliebre-Lara V, Monzote Fidalgo L, Pferschy-Wenzig EM, Kunert O, Nogueiras Lima C, Bauer R (2016). In Vitro Antileishmanial Activity of Sterols from Trametes versicolor (Bres. Rivarden). Molecules (Basel, Switzerland) https://doi.org/10.3390/molecules21081045 PMID: 27517895

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