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Mesima, Sanghwang · 2018 · Research Article

High relevance

Hepatoprotective Principles and Other Chemical Constituents from the Mycelium of Phellinus linteus.

Phellinus linteus

OncologyLiver support
SpeciesMesima, Sanghwang
JournalMolecules (Basel, Switzerland)
Year2018

Key points

  • In the dimethylnitrosamine (DMN)-induced hepatic fibrosis Wistar rat model, the mycelium extract of Phellinus linteus (PLE) (20 mg/Kg) displayed significant protection against hepatic fibrosis
  • The present investigation characterized eleven new ionone derivatives, phellinulins D⁻N ( 4 ⁻ 14 ), from the P. linteus mycelium extract and the relative stereochemical structures were constructed according to the spectroscopic and spectrometric analytical results
  • Some purified compounds were examined for their inhibitory effects on activated rat hepatic stellate cells (HSCs) and several isolates did exhibit significant protection
  • The results indicated that the mycelium of P. linteus could be explored as a hepatoprotective drug or healthy food candidate in the near future

Metadata-grounded summary

Citation abstract

In the dimethylnitrosamine (DMN)-induced hepatic fibrosis Wistar rat model, the mycelium extract of Phellinus linteus (PLE) (20 mg/Kg) displayed significant protection against hepatic fibrosis. The present investigation characterized eleven new ionone derivatives, phellinulins D⁻N ( 4 ⁻ 14 ), from the P. linteus mycelium extract and the relative stereochemical structures were constructed according to the spectroscopic and spectrometric analytical results. Some purified compounds were examined for their inhibitory effects on activated rat hepatic stellate cells (HSCs) and several isolates did exhibit significant protection. The results indicated that the mycelium of P. linteus could be explored as a hepatoprotective drug or healthy food candidate in the near future.

Citation

Huang SC, Wang PW, Kuo PC, Hung HY, Pan TL (2018). Hepatoprotective Principles and Other Chemical Constituents from the Mycelium of Phellinus linteus. Molecules (Basel, Switzerland) https://doi.org/10.3390/molecules23071705 PMID: 30002357

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