Antifungal Activity against Botrytis cinerea of 2,6-Dimethoxy-4-(phenylimino)cyclohexa-2,5-dienone Derivatives.

Trametes versicolor

SpeciesTurkey Tail, Yun Zhi

JournalMolecules (Basel, Switzerland)

Year2019

Key points

In this work the enzyme laccase from Trametes versicolor was used to synthetize 2,6-dimethoxy-4-(phenylimino)cyclohexa-2,5-dienone derivatives
Ten products with different substitutions in the aromatic ring were synthetized and characterized using ¹H- and 13C-NMR and mass spectrometry
The 3,5-dichlorinated compound showed highest antifungal activity against the phytopathogen Botrytis cinerea, while the p-methoxylated compound had the lowest activity; however, the antifungal activity of the products was higher than the activity of the substrates of the reactions
Finally, the results suggested that these compounds produced damage in the fungal cell wall

From the paper

Abstract

In this work the enzyme laccase from Trametes versicolor was used to synthetize 2,6-dimethoxy-4-(phenylimino)cyclohexa-2,5-dienone derivatives. Ten products with different substitutions in the aromatic ring were synthetized and characterized using ¹H- and 13C-NMR and mass spectrometry. The 3,5-dichlorinated compound showed highest antifungal activity against the phytopathogen Botrytis cinerea, while the p-methoxylated compound had the lowest activity; however, the antifungal activity of the products was higher than the activity of the substrates of the reactions. Finally, the results suggested that these compounds produced damage in the fungal cell wall.

Citation

Castro P, Mendoza L, Vásquez C, Pereira PC, Navarro F, Lizama K, et al. (2019). Antifungal Activity against Botrytis cinerea of 2,6-Dimethoxy-4-(phenylimino)cyclohexa-2,5-dienone Derivatives. Molecules (Basel, Switzerland) https://doi.org/10.3390/molecules24040706 PMID: 30781370

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