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Lion's Mane, Yamabushitake · 2022 · Research Article

High relevance

Hericium erinaceus Mycelium Ameliorates In Vivo Progression of Osteoarthritis.

Hericium erinaceus

Cognition & nerves
SpeciesLion's Mane, Yamabushitake
JournalNutrients
Year2022

Key points

  • Osteoarthritis (OA) is an age-related disorder that affects the joints and causes functional disability
  • However, the therapeutic effects of H. erinaceus in OA are unknown
  • In this study, data from Sprague-Dawley rats with knee OA induced by anterior cruciate ligament transection (ACLT) indicated that H. erinaceus mycelium improves ACLT-induced weight-bearing asymmetry and minimizes pain
  • ACLT-induced increases in articular cartilage degradation and bone erosion were significantly reduced by treatment with H. erinaceus mycelium
  • In addition, H. erinaceus mycelium reduced the synthesis of proinflammatory cytokines interleukin-1β and tumor necrosis factor-α in OA cartilage and synovium
  • H. erinaceus mycelium shows promise as a functional food in the treatment of OA

Metadata-grounded summary

Citation abstract

Osteoarthritis (OA) is an age-related disorder that affects the joints and causes functional disability. Hericium erinaceus is a large edible mushroom with several known medicinal functions. However, the therapeutic effects of H. erinaceus in OA are unknown. In this study, data from Sprague-Dawley rats with knee OA induced by anterior cruciate ligament transection (ACLT) indicated that H. erinaceus mycelium improves ACLT-induced weight-bearing asymmetry and minimizes pain. ACLT-induced increases in articular cartilage degradation and bone erosion were significantly reduced by treatment with H. erinaceus mycelium. In addition, H. erinaceus mycelium reduced the synthesis of proinflammatory cytokines interleukin-1β and tumor necrosis factor-α in OA cartilage and synovium. H. erinaceus mycelium shows promise as a functional food in the treatment of OA.

Citation

Yang SY, Fang CJ, Chen YW, Chen WP, Lee LY, Chen CC, et al. (2022). Hericium erinaceus Mycelium Ameliorates In Vivo Progression of Osteoarthritis. Nutrients https://doi.org/10.3390/nu14132605 PMID: 35807786

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